New York City’s dynamic and exploratory art scene of the early 1930s included exposure to the bold work being done by Los Tres Grandes—José Clemente Orozco, Diego Rivera, and David Siqueiros—the “Big Three” of Mexico’s muralism movement.

Somewhere around 1940, Annette was chosen to work side-by-side with Orozco on Four Horsemen of the Apocalypse in downtown Mexico City.